Currently, MRCP has innumerable indications, such as evaluation of the normal biliary anatomy and its variants, and congenital and acquired biliary pathologies 2. Magnetic Resonance Cholangiopancreatography (MRCP) is the first-line non-invasive imaging technique for evaluating the biliary tract if immediate therapy for a known problem is not the primary aim 1. The optimized single-dose oral administration of 150 ml (approximately one glass) of PJ having a high Mn 2+ concentration prior to MRCP was adequate to guarantee the correct amount of Mn 2+ to suppress the GD signal. A total amount of 150 ml (one glass) of PJ having a high Mn 2+ content (2.37 mg/dl) was sufficient for the suppression of the GD liquid signal, despite the additional dilution caused by GD liquids since it led to a final concentration of Mn 2+ of 0.5–1.00 mg/dl. The concentrations of Mn 2+ in commercial PJ produced in different years did not differ. The results were compared with those achieved with the previous standard amount of PJ used in a similar population. The optimal Mn 2+ concentration and the amount of PJ, were estimated in an in-vitro analysis, and were then prospectively tested in a population of patients who underwent MRCP. The Mn 2+ concentration in PJ produced in different years was defined using Atomic Absorption Spectrometry. To evaluate the potential variability of Manganese (Mn 2+) in commercial pineapple juice (PJ) produced in different years and to identify the optimal Mn 2+ concentration in the correct amount of PJ to be administered prior to Magnetic Resonance Cholangiopancreatography (MRCP) in order to suppress the gastroduodenal (GD) liquid signal.
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